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"Stealth surgery": transaxillary subcutaneous endoscopic excision of benign neck lesions.
Gating dynamics of the acetylcholine receptor extracellular domain.
Principal Investigator
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Schreiber, Hans
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Schreiber, Hans
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overview
The main focus of this laboratory is to study the fundamental mechanisms that govern the interaction of cancer cells with the immune system. In particular, our laboratory is trying to exploit the fact that cancer cells usually carry cancer-specific mutations and antigens, and that under certain conditions, the immune system can destroy cancer cells even after they have disseminated in the body. We are trying to understand the mechanisms that often allow immunogenic cancer cells to escape immune destruction, and we want to develop new strategies and principles on which to base novel therapeutic approaches. We are also studying the signals needed for the immune system to be alerted be cancer cells, and then to destroy these cells. Finally, we combine immunology with genetics and biochemistry, which provides us with a powerful tool to search for cancer-specific changes in malignant cells in order to identify critical mechanisms and immunological targets that can be used to destroy the cancer.
One or more keywords matched the following items that are connected to
Schreiber, Hans
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Breast Neoplasms
Concept
Bone Neoplasms
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Colonic Neoplasms
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Uterine Cervical Neoplasms
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Digestive System Neoplasms
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Facial Neoplasms
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Mammary Neoplasms, Experimental
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Neoplasms, Radiation-Induced
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Pancreatic Neoplasms
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Ovarian Neoplasms
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Lung Neoplasms
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Prostatic Neoplasms
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Rectal Neoplasms
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Vaginal Neoplasms
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Transplantation Immunology
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Mouth Neoplasms
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Neoplasms, Experimental
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Cancer Vaccines
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Peritoneal Neoplasms
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Stomach Neoplasms
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Skin Neoplasms
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Colorectal Neoplasms
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Brain Neoplasms
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Neoplasms
Academic Article
A tumor escape variant that has lost one major histocompatibility complex class I restriction element induces specific CD8+ T cells to an antigen that no longer serves as a target.
Academic Article
DNA sequence analysis of T-cell receptor genes reveals an oligoclonal T-cell response to a tumor with multiple target antigens.
Academic Article
Prevention of runting and cachexia by a chimeric TNF receptor-Fc protein.
Academic Article
Footprinting of individual tumors and their variants by constitutive cytokine expression patterns.
Academic Article
Genetically engineered vaccines. Comparison of active versus passive immunotherapy against solid tumors.
Academic Article
Antigenic cancer cells grow progressively in immune hosts without evidence for T cell exhaustion or systemic anergy.
Academic Article
Immunodominance deters the response to other tumor antigens thereby favoring escape: prevention by vaccination with tumor variants selected with cloned cytolytic T cells in vitro.
Academic Article
The immunodominant antigen of an ultraviolet-induced regressor tumor is generated by a somatic point mutation in the DEAD box helicase p68.
Academic Article
Radiation can inhibit tumor growth indirectly while depleting circulating leukocytes.
Academic Article
Immunological enhancement of primary tumor development and its prevention.
Academic Article
Tracking the common ancestry of antigenically distinct cancer variants.
Academic Article
Point mutation in essential genes with loss or mutation of the second allele: relevance to the retention of tumor-specific antigens.
Academic Article
Enhanced eradication of local and distant tumors by genetically produced interleukin-12 and radiation.
Academic Article
Tumor antigens.
Academic Article
Enhanced growth of primary tumors in cancer-prone mice after immunization against the mutant region of an inherited oncoprotein.
Academic Article
Establishment of an HLA-A*0201 human papillomavirus type 16 tumor model to determine the efficacy of vaccination strategies in HLA-A*0201 transgenic mice.
Academic Article
Role of TGF-beta in immune-evasion of cancer.
Academic Article
MHC class I restricted T cells and immune surveillance against transplanted ultraviolet light-induced tumors.
Academic Article
C-kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum.
Academic Article
Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation.
Academic Article
Strong synergy between mutant ras and HPV16 E6/E7 in the development of primary tumors.
Academic Article
Genetic changes occurring in established tumors rapidly stimulate new antibody responses.
Academic Article
A new murine tumor model for studying HLA-A2-restricted anti-tumor immunity.
Academic Article
A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance.
Academic Article
Intratumor depletion of CD4+ cells unmasks tumor immunogenicity leading to the rejection of late-stage tumors.
Academic Article
The role of stroma in immune recognition and destruction of well-established solid tumors.
Academic Article
Long-term suppression of tumor growth by TNF requires a Stat1- and IFN regulatory factor 1-dependent IFN-gamma pathway but not IL-12 or IL-18.
Academic Article
The terminology issue for myeloid-derived suppressor cells.
Academic Article
Cancer immunotherapy and preclinical studies: why we are not wasting our time with animal experiments.
Academic Article
Mechanism of tumor rejection in anti-CD3 monoclonal antibody-treated mice.
Academic Article
Inflammation as a tumor promoter in cancer induction.
Academic Article
Specificity in cancer immunotherapy.
Academic Article
Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
Academic Article
Ribosomal versus non-ribosomal cellular antigens: factors determining efficiency of indirect presentation to CD4+ T cells.
Academic Article
Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity.
Academic Article
Densely granulated murine NK cells eradicate large solid tumors.
Academic Article
Cancer. Quo vadis, specificity?
Academic Article
Progression of cancer from indolent to aggressive despite antigen retention and increased expression of interferon-gamma inducible genes.
Academic Article
IFN-gamma- and TNF-dependent bystander eradication of antigen-loss variants in established mouse cancers.
Academic Article
Rapid destruction of the tumor microenvironment by CTLs recognizing cancer-specific antigens cross-presented by stromal cells.
Academic Article
Long-term inhibition of tumor growth by tumor necrosis factor in the absence of cachexia or T-cell immunity.
Academic Article
Antigenic cancer cells that escape immune destruction are stimulated by host cells.
Academic Article
Recurrence of intracranial tumors following adoptive T cell therapy can be prevented by direct and indirect killing aided by high levels of tumor antigen cross-presented on stromal cells.
Academic Article
Targeting stroma to treat cancers.
Academic Article
CD40 ligation restores cytolytic T lymphocyte response and eliminates fibrosarcoma in the peritoneum of mice lacking CD4+ T cells.
Academic Article
Spleen cells from young but not old immunized mice eradicate large established cancers.
Academic Article
Relationship of tumour necrosis factor and endotoxin to macrophage cytotoxicity, haemorrhagic necrosis and lethal shock.
Academic Article
A unique tumor antigen produced by a single amino acid substitution.
Academic Article
Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.
Academic Article
Cancer. Awakening immunity.
Academic Article
Unique tumor-specific antigens.
Academic Article
Identification of a gene encoding a tumor-specific antigen that causes tumor rejection.
Academic Article
Tumor antigens defined by cloned immunological probes are highly polymorphic and are not detected on autologous normal cells.
Academic Article
[CA 12-5 in cancer of the digestive tract. A comparison with CA 19-9 and CEA in cancer of the pancreas and colon].
Academic Article
Antiproliferative effects exerted by recombinant human tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human pancreatic tumor cell lines.
Academic Article
CD4+ and B lymphocytes in transplantation immunity. II. Augmented rejection of tumor allografts by mice lacking B cells.
Academic Article
Targeting the primary tumor to generate CTL for the effective eradication of spontaneous metastases.
Academic Article
CD4-positive and B lymphocytes in transplantation immunity. I. Promotion of tumor allograft rejection through elimination of CD4-positive lymphocytes.
Academic Article
Equilibrium between host and cancer caused by effector T cells killing tumor stroma.
Academic Article
Animals bearing malignant grafts reject normal grafts that express through gene transfer the same antigen.
Academic Article
Tumor-specific immune responses.
Academic Article
Signal integration: a framework for understanding the efficacy of therapeutics targeting the human EGFR family.
Academic Article
[Immunocytologic detection of disseminated tumor cells in the peritoneal cavity and bone marrow in patients with pancreatic carcinoma].
Academic Article
Stroma is critical for preventing or permitting immunological destruction of antigenic cancer cells.
Academic Article
Inhibition of tumor growth by elimination of granulocytes.
Academic Article
CD4(+) T cells eliminate MHC class II-negative cancer cells in vivo by indirect effects of IFN-gamma.
Academic Article
Immunodominance and tumor escape.
Academic Article
Increasing tumor antigen expression overcomes "ignorance" to solid tumors via crosspresentation by bone marrow-derived stromal cells.
Academic Article
Bystander elimination of antigen loss variants in established tumors.
Academic Article
Major histocompatibility complex class I and unique antigen expression by murine tumors that escaped from CD8+ T-cell-dependent surveillance.
Academic Article
Bystander killing of cancer requires the cooperation of CD4(+) and CD8(+) T cells during the effector phase.
Academic Article
In vivo administration of anti-CD3 prevents malignant progressor tumor growth.
Academic Article
Tumors with reduced expression of a cytotoxic T lymphocyte recognized antigen lack immunogenicity but retain sensitivity to lysis by cytotoxic T lymphocytes.
Academic Article
Immunocytological detection of micrometastatic cells: comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients.
Academic Article
Isolated tumor cells are frequently detectable in the peritoneal cavity of gastric and colorectal cancer patients and serve as a new prognostic marker.
Academic Article
IL-15 in tumor microenvironment causes rejection of large established tumors by T cells in a noncognate T cell receptor-dependent manner.
Academic Article
Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity.
Academic Article
MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR.
Academic Article
[Clinical aspects and therapy of Merkel cell tumor--report of 4 personal cases and review of the literature].
Academic Article
Innate and adaptive immune cells in the tumor microenvironment.
Academic Article
Editorial overview: tumour immunology.
Academic Article
Adoptively transferred immune T cells eradicate established tumors despite cancer-induced immune suppression.
Academic Article
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors--letter.
Academic Article
Antigen-specific bacterial vaccine combined with anti-PD-L1 rescues dysfunctional endogenous T cells to reject long-established cancer.
Academic Article
Targeting cancer-specific mutations by T cell receptor gene therapy.
Academic Article
Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.
Academic Article
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma.
Academic Article
Tumor-associated fibroblasts predominantly come from local and not circulating precursors.
Academic Article
Transfer of Allogeneic CD4+ T Cells Rescues CD8+ T Cells in Anti-PD-L1-Resistant Tumors Leading to Tumor Eradication.
Academic Article
Tumour ischaemia by interferon-? resembles physiological blood vessel regression.
Academic Article
Active immunization against cancer cells: impediments and advances.
Academic Article
Fibroblasts: Dangerous travel companions.
Academic Article
A strategy for generating cancer-specific monoclonal antibodies to aberrant O-glycoproteins: identification of a novel dysadherin-Tn antibody.
Academic Article
Neoadjuvant PD-1 Immune Checkpoint Blockade Reverses Functional Immunodominance among Tumor Antigen-Specific T Cells.
Academic Article
Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.
Academic Article
Multiple cancer-specific antigens are targeted by a chimeric antigen receptor on a single cancer cell.
Academic Article
Impact of TCR Diversity on the Development of Transplanted or Chemically Induced Tumors.
Academic Article
Cooperation of genes in HPV16 E6/E7-dependent cervicovaginal carcinogenesis trackable by endoscopy and independent of exogenous estrogens or carcinogens.
Academic Article
LyP-1-Modified Oncolytic Adenoviruses Targeting Transforming Growth Factor ß Inhibit Tumor Growth and Metastases and Augment Immune Checkpoint Inhibitor Therapy in Breast Cancer Mouse Models.
Academic Article
Criteria to make animal studies more relevant to treating human cancer.
Concept
Cancer-Associated Fibroblasts
Grant
Three Laser BD Digital LSR
Grant
CD8+ T cells and Immunological Tumor Regression
Grant
TRANSFORMING GENES AND IMMUNOLOGICAL TUMOR REGRESSION
Grant
Manipulation of Tumor Specific Immunity
Grant
Interdisciplinary Training Program in Immunology
Grant
IMMUNITY AND CANCER
Grant
MANIPULATION OF TUMOR-SPECIFIC IMMUNITY
Grant
Immunology of Unique Tumor Specific Antigens
Academic Article
Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model.
Academic Article
One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication.
Academic Article
The safety and efficacy of systemic delivery of a new liver-de-targeted TGFß signaling inhibiting adenovirus in an immunocompetent triple negative mouse mammary tumor model.
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Cancer
Immunology